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Awarded Trial: 09T-1280

Grant ID

09T-1280

Illness

Bipolar Depression

Primary Drug/Intervention

Pregnenolone

Primary Dosage

500 mg/day

Secondary Drug Intervention

N/A

Secondary Dosage

N/A

Other Drug/Intervention

N/A

Other Dosage

N/A

Status

Completed

Investigator

Brown

Sample Size

80

Duration of Study Period for Each Subject

84

Outcome Measurements

N/A

Results

Eighty patients with bipolar disorder depression were randomized to receive either pregnenolone or placebo as an add-on medication. Pregnenolone was associated with improvement in depression using measures from the Hamilton Rating Scale for Depression (HRSD). Secondary outcome measures of the Inventory of Depressive Symptomatology-SR (IDS-SR) were negative. Reductions in anxiety symptoms were also not significant.

Publication

N/A

Link

N/A

PI Name

E. Sherwood Brown

Degree

MD

Center

N/A

Institution

University of Texas Southwestern Medical Center at Dallas

Address

5323 Harry Hines Blvd, MC 8849

City or Town

Dallas

State or Province

Texas

Zip or Postal Code

75390-8849

Country

USA

Email Address

sherwood.brown@utsouthwestern.edu