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Awarded Trial: 00-016
Grant ID
00-016
Illness
Bipolar Disorder
Primary Drug/Intervention
Lithium
Primary Dosage
300 mg/bid titrated in 300 mg increments every 7 days as tolerated to levels of at least 0.8 mEq/L
Secondary Drug Intervention
Divalproex
Secondary Dosage
250 mg/bid titrated in 250 mg increments every 7 days as tolerated to levels of at least 50 ug/ml
Other Drug/Intervention
Lamotrigine
Other Dosage
25-300 mg
Status
Completed
Investigator
Calabrese
Sample Size
240
Duration of Study Period for Each Subject
6 months
Outcome Measurements
MADRS, YMRS, GAS, CGI
Results
N/A
Publication
Kemp DE, Gao K, Fein EB, Chan PK, Conroy C, Obral S, Ganocy SJ, Calabrese JR. Lamotrigine as add-on treatment to lithium and divalproex: lessons learned from a double-blind, placebo-controlled trial in rapid-cycling bipolar disorder. Bipolar Disord. 2012;14(7):780-789.
Link
http://www.ncbi.nlm.nih.gov/pubmed/23107222
PI Name
Joseph Calabrese
Degree
MD
Center
Case Western Reserve University
Institution
University Hospitals of Cleveland
Address
11400 Euclid Avenue, Suite 200
City or Town
Cleveland
State or Province
OH
Zip or Postal Code
44106
Country
USA
Email Address
joseph.calabrese@uhhs.com