Awarded Trial: 00-105
Secondary Drug Intervention
Duration of Study Period for Each Subject
PANSS, Cognitive measures
69 patients with schizophrenia were randomized to receive transdermal estradiol or placebo. Patients receiving estrogen treatment showed significant improvements in PANSS total, PANSS positive, PANSS negative and PANSS general symptom ratings. Estrogen-treated patients also showed significant benefit on measures of short-term memory.
Arch Womens Ment Health. 2002 Nov;5(3):99-104. A clinical trial of adjunctive oestrogen treatment in women with schizophrenia. Kulkarni J1, Riedel A, de Castella AR, Fitzgerald PB, Rolfe TJ, Taffe J, Burger H.
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