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Awarded Trial: 01-025
Grant ID
01-025
Illness
Schizophrenia
Primary Drug/Intervention
Repeated Transcranial Magnetic Stimulation (rTMS)
Primary Dosage
1 Hz
Secondary Drug Intervention
N/A
Secondary Dosage
N/A
Other Drug/Intervention
N/A
Other Dosage
N/A
Status
Completed
Investigator
Fitzgerald
Sample Size
33
Duration of Study Period for Each Subject
2 weeks
Outcome Measurements
Hullucination Change Scale, PSYRATS, PANSS, Hopkins Verbal Learning Test, Verbal Fluency, Digit Span, Brief Visuospatial Memory Test-Revised, Visuospatial Digit Span
Results
Thirty three patients with treatment resistant auditory hallucinations were randomized to receive rTMS or sham for 10 consecutive days over the temporoparietal cortex. The treatment was for 15 minutes at 1 Hz and 90% of resting motor threshold. There was no clinically significant difference between active and sham treatment, but a modest reduction in the loudness of hallucinations was observed.
Publication
Fitzgerald PB, Brown TL, Marston NA, Daskalakis ZJ, De Castella A, Kulkarni J. Transcranial magnetic stimulation in the treatment of depression: a double-blind, placebo-controlled trial. Arch Gen Psychiatry. 2003 Oct;60(10):1002-8.
Link
http://www.ncbi.nlm.nih.gov/pubmed/14557145
PI Name
Paul Fitzgerald
Degree
MBBS
Center
Alfred Psychiatry Research Centre
Institution
The Alfred Hospital
Address
Commercial Road
City or Town
Prahran
State or Province
Victoria
Zip or Postal Code
3181
Country
Australia
Email Address
p.fitzgerald@alfred.org.au