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Awarded Trial: 01-RC-310-2
Grant ID
01-RC-310-2
Illness
Bipolar Depression
Primary Drug/Intervention
Venlafaxine
Primary Dosage
37.5 mg twice daily - allowing for 75mg/day increments every week
Secondary Drug Intervention
Paroxetine
Secondary Dosage
20 mg/day - allowing for 10mg/day increments every week
Other Drug/Intervention
N/A
Other Dosage
N/A
Status
Completed
Investigator
Vieta
Sample Size
60
Duration of Study Period for Each Subject
6 weeks
Outcome Measurements
HAM-D, YMRS
Results
Sixty patients with bipolar depression were randomized to receive paroxetine or venlafaxine given adjunctively to mood stabilizers. Both groups responded equally well, but 3% of patients given paroxetine and 13% of patients given venlafxine experienced a switch to mania.
Publication
Vieta E, Martinez-Aran A, Goikolea JM, Torrent C, Colom F, Benabarre A, Reinares M. A randomized trial comparing paroxetine and venlafaxine in the treatment of bipolar depressed patients taking mood stabilizers. J Clin Psychiatry 2002;63:508-512.
Link
http://www.ncbi.nlm.nih.gov/pubmed/12088162
PI Name
Eduard Vieta
Degree
MD
Center
N/A
Institution
Fundacio Clinic Per A La Recerca Biomedica
Address
C/Villarroel, 170
City or Town
Barcelona
State or Province
N/A
Zip or Postal Code
8025
Country
Spain
Email Address
evieta@clinic.ub.es