Awarded Trial: 01-RC-310-2
37.5 mg twice daily - allowing for 75mg/day increments every week
Secondary Drug Intervention
20 mg/day - allowing for 10mg/day increments every week
Duration of Study Period for Each Subject
Sixty patients with bipolar depression were randomized to receive paroxetine or venlafaxine given adjunctively to mood stabilizers. Both groups responded equally well, but 3% of patients given paroxetine and 13% of patients given venlafxine experienced a switch to mania.
Vieta E, Martinez-Aran A, Goikolea JM, Torrent C, Colom F, Benabarre A, Reinares M. A randomized trial comparing paroxetine and venlafaxine in the treatment of bipolar depressed patients taking mood stabilizers. J Clin Psychiatry 2002;63:508-512.
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