Grant ID

01T-045

Illness

Bipolar Disorder

Primary Drug/Intervention

Tryptophan

Primary Dosage

1.5g-3g

Secondary Drug Intervention

Branch Chain Amino Acids

Secondary Dosage

30g-60g

Other Drug/Intervention

N/A

Other Dosage

N/A

Status

Completed

Investigator

Goodwin

Sample Size

20

Duration of Study Period for Each Subject

7 days

Outcome Measurements

YMRS

Results

Twenty patients with acute mania were enrolled. Relative to placebo the drink containing tryptophan and branch chain amino acids lowered mania ratings acutely and over two weeks.

Publication

Elmslie JL, Porter RJ, Joyce PR, Hunt PJ, Mann JI. Carnitine does not improve weight loss outcomes in valproate-treated bipolar patients consuming an energy-restricted, low-fat diet. Bipolar Disord. 2006 Oct;8(5 Pt 1):503-7.

Link

http://www.ncbi.nlm.nih.gov/pubmed/17042889

PI Name

Guy Goodwin

Degree

FRCPsych

Center

University of Oxford, University Department

Institution

Warneford Hospital

Address

City or Town

Oxford

State or Province

Oxfordshire

Zip or Postal Code

OX3 7JX

Country

United Kingdom

Email Address

guy.goodwin@psych.ox.ac.uk