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Awarded Trial: 01T-096
Grant ID
01T-096
Illness
Schizophrenia
Primary Drug/Intervention
Donepezil
Primary Dosage
10 mg
Secondary Drug Intervention
N/A
Secondary Dosage
N/A
Other Drug/Intervention
N/A
Other Dosage
N/A
Status
Completed
Investigator
Kohler
Sample Size
90
Duration of Study Period for Each Subject
16 weeks
Outcome Measurements
BPRS, Cognitive Battery
Results
Forty-eight patients were randomized and completed the trial. There was no significant effect of donepezil on cognitive performance or on psychiatric symptom ratings.
Publication
Kohler CG1, Martin EA, Kujawski E, Bilker W, Gur RE, Gur RC. No effect of donepezil on neurocognition and social cognition in young persons with stable schizophrenia. Cogn Neuropsychiatry. 2007 Sep;12(5):412-21.
Link
http://www.ncbi.nlm.nih.gov/pubmed/17690999
PI Name
Christian Kohler
Degree
MD
Center
N/A
Institution
University of Pennsylvania
Address
3400 Spruce Street, 10 Gates
City or Town
Philedelphia
State or Province
PA
Zip or Postal Code
19104
Country
USA
Email Address
kohler@bbl.med.upenn.edu