Back to Awarded Treatment Trials


Awarded Trial: 01T-101

Grant ID

01T-101

Illness

Schizophrenia

Primary Drug/Intervention

Allopurinol

Primary Dosage

300 mg b.i.d.

Secondary Drug Intervention

N/A

Secondary Dosage

N/A

Other Drug/Intervention

N/A

Other Dosage

N/A

Status

Completed

Investigator

Lara

Sample Size

35

Duration of Study Period for Each Subject

12 weeks

Outcome Measurements

PANSS, extrapyramidal symptoms rating scale, electrophysiological recordings, MANOVA

Results

A double blind, randomized, placebo-controlled crossover study of adjunctive allopurinol in 35 patients with poorly responsive schizophrenia was conducted. Allopurinol was well tolerated and produced significant treatment effects on the PANSS total score as well as the positive, negative, and general subscales.

Publication

Brunstein MG, Ghisolfi ES, Ramos FL, Lara DR. A clinical trial of adjuvant allopurinol therapy in moderately refractory schizophrenia. J Clin Psychiatry. 2005 Feb;66(2):213-9.

Link

http://www.ncbi.nlm.nih.gov/pubmed/15705007

PI Name

Diogo Lara

Degree

MD

Center

Faculdade de Biociencias

Institution

Pontificia Universidade Catolica PUCRS

Address

Av. Ipiranga, 6681, Pd 12 A

City or Town

Porto Alegre

State or Province

RS

Zip or Postal Code

90619-900

Country

Brazil

Email Address

drlara@pucrs.br