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Awarded Trial: 01T-101
Grant ID
01T-101
Illness
Schizophrenia
Primary Drug/Intervention
Allopurinol
Primary Dosage
300 mg b.i.d.
Secondary Drug Intervention
N/A
Secondary Dosage
N/A
Other Drug/Intervention
N/A
Other Dosage
N/A
Status
Completed
Investigator
Lara
Sample Size
35
Duration of Study Period for Each Subject
12 weeks
Outcome Measurements
PANSS, extrapyramidal symptoms rating scale, electrophysiological recordings, MANOVA
Results
A double blind, randomized, placebo-controlled crossover study of adjunctive allopurinol in 35 patients with poorly responsive schizophrenia was conducted. Allopurinol was well tolerated and produced significant treatment effects on the PANSS total score as well as the positive, negative, and general subscales.
Publication
Brunstein MG, Ghisolfi ES, Ramos FL, Lara DR. A clinical trial of adjuvant allopurinol therapy in moderately refractory schizophrenia. J Clin Psychiatry. 2005 Feb;66(2):213-9.
Link
http://www.ncbi.nlm.nih.gov/pubmed/15705007
PI Name
Diogo Lara
Degree
MD
Center
Faculdade de Biociencias
Institution
Pontificia Universidade Catolica PUCRS
Address
Av. Ipiranga, 6681, Pd 12 A
City or Town
Porto Alegre
State or Province
RS
Zip or Postal Code
90619-900
Country
Brazil
Email Address
drlara@pucrs.br