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Awarded Trial: 01T-437
Grant ID
01T-437
Illness
Schizophrenia
Primary Drug/Intervention
Clotiapine
Primary Dosage
flexible dose
Secondary Drug Intervention
N/A
Secondary Dosage
N/A
Other Drug/Intervention
N/A
Other Dosage
N/A
Status
Completed
Investigator
Belmaker
Sample Size
60
Duration of Study Period for Each Subject
3 months
Outcome Measurements
PANSS, CGI, NOSIE
Results
Fifty eight patients with schizophrenia and residual psychosis despite treatment with 3 neuroleptics were randomized. Thirty three patients completed the study. Clotiapine was superior to chlorpromazine on PANSS ratings (16% vs -1.6% change from baseline), CGI ratings (16.9% vs. 0%) and NOSIE ratings (10% vs. -3%).
Publication
Geller V, Gorzaltsan I, Shleifer T, Belmaker RH, Bersudsky Y. Clotiapine compared with clozapine in chronic schizophrenia. Schizophr Res. 2005 Dec 15;80(2-3):343-7.
Link
http://www.ncbi.nlm.nih.gov/pubmed/16126373
PI Name
Robert Belmaker
Degree
MD
Center
Beersheva Mental Health Center
Institution
Ben-Gurion University
Address
P.O. Box 4600
City or Town
Beersheva
State or Province
N/A
Zip or Postal Code
N/A
Country
Israel
Email Address
belmaker@bgu.ac.il