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Awarded Trial: 01T-407
Grant ID
01T-407
Illness
Schizophrenia
Primary Drug/Intervention
Modafinil
Primary Dosage
200 mg
Secondary Drug Intervention
N/A
Secondary Dosage
N/A
Other Drug/Intervention
N/A
Other Dosage
N/A
Status
Completed
Investigator
Pierre
Sample Size
20
Duration of Study Period for Each Subject
8 weeks
Outcome Measurements
SANS, BPRS, CGI, QOL, CVLT, DS-CPT, Trails B, Somatic Measurements (Sleep, Weight, Glucose, Lipids)
Results
Twenty patients with schizophrenia were randomized to receive modafanil 200 mg given adjunctively to antipsychotics or placebo for 8 weeks. Modafinil treatment had no effect on SANS, BPRS, quality of life or cognitive scales.
Publication
Pierre JM, Peloian JH, Wirshing DA, Wirshing WC, Marder SR. A Randomized, Double-Blind, Placebo-Controlled Trial of Modafinil for Negative Symptoms in Schizophrenia. J Clin Psychiatry. 2007 May;68(5):705-10.
Link
http://www.ncbi.nlm.nih.gov/pubmed/17503979
PI Name
Joseph Pierre
Degree
MD
Center
N/A
Institution
VA Greater Los Angeles Health Care System
Address
11301 Wilshire Blvd, Bldg. 210 A, B-151H
City or Town
Los Angeles
State or Province
CA
Zip or Postal Code
90073
Country
USA
Email Address
drjoe@ucla.edu