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Awarded Trial: 02T-144

Grant ID

02T-144

Illness

BP

Primary Drug/Intervention

Chronobiological acceleration package (sleep deprivation/phase advance)

Primary Dosage

N/A

Secondary Drug Intervention

N/A

Secondary Dosage

N/A

Other Drug/Intervention

N/A

Other Dosage

N/A

Status

Completed

Investigator

Wu

Sample Size

62

Duration of Study Period for Each Subject

6 weeks

Outcome Measurements

HAM-D

Results

Patients with bipolar depression were randomized to receive standard psychotropic medication, or medication plus the chronobiological acceleration package. The chronobiological acceleration package included sleep deprivation, light treatment and phase advance of sleep. Patients receiving the acceleration package had a more rapid and robust antidepressant response than those receiving medication alone.

Publication

N/A

Link

N/A

PI Name

Joseph Wu

Degree

MD

Center

Department of Psychiatry and Human Behavior

Institution

The University of California, Irvine

Address

Brain Imaging Center, Irvine Hall

City or Town

Irvine

State or Province

CA

Zip or Postal Code

92697

Country

USA

Email Address

jcwu@uci.edu