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Awarded Trial: 02T-255
Grant ID
02T-255
Illness
Schizophrenia
Primary Drug/Intervention
Pregnenolone
Primary Dosage
100mg-500mg
Secondary Drug Intervention
N/A
Secondary Dosage
N/A
Other Drug/Intervention
N/A
Other Dosage
N/A
Status
Completed
Investigator
Savitz
Sample Size
32
Duration of Study Period for Each Subject
10 weeks
Outcome Measurements
PANSS, SANS
Results
Thirty-two patients with schizophrenia were randomized to receive placebo, low dose pregnenolone (100 mg), rapid escalation to high dose pregnenolone (500 mg) and slow escalation to high dose pregnenolone (500 mg) given adjunctively to antipsychotics. The group receiving rapid escalation to high dose pregnenolone showed significant improvements in PANSS total scores, PANSS negative scores, SANS total scores. Pregnenolone also seemed to improve verbal memory and sustained attention. Pregnenolone is a precursor of steroid hormones and is a glutamate NMDA receptor agonist.
Publication
N/A
Link
N/A
PI Name
Adam Savitz
Degree
MD
Center
NYPH Payne Whitney Westchester
Institution
Weill Medical College of Cornell University
Address
21 Bloomingdale Road
City or Town
White Plains
State or Province
NY
Zip or Postal Code
10605
Country
USA
Email Address
ads9002@med.cornell.edu