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Awarded Trial: 02T-125
Grant ID
02T-125
Illness
Tardive Movement Disorders
Primary Drug/Intervention
Vitamin B6
Primary Dosage
600 mg b.i.d.
Secondary Drug Intervention
N/A
Secondary Dosage
N/A
Other Drug/Intervention
N/A
Other Dosage
N/A
Status
Completed
Investigator
Lerner
Sample Size
50
Duration of Study Period for Each Subject
12 weeks
Outcome Measurements
Extrapyramidal Symptom Rating Scale
Results
Fifty patients were randomized and 36 patients completed the study. In a preliminary analysis patients receiving vitamin B6 experienced a significant reduction in scores for tardive parkinsonism (63%), tardive tremor (65%) and tardive dyskinesia (48%).
Publication
Lerner, V, Miodownik C, Kaptsan A, Bersudsky Y, Libov I, Sela BA, Witztum E. Vitamin B6 treatment for tardive dyskinesia: a randomized, double-blind, placebo-controlled, crossover study. J Clin Psychiatry. 2007 Nov;68(11):1648-54.
Link
http://www.ncbi.nlm.nih.gov/pubmed/18052557
PI Name
Vladimir Lerner
Degree
MD
Center
Be'er Sheva Mental Health Center
Institution
Ben Gurion University of the Negev
Address
P.O. Box 4600
City or Town
Be'er Sheva
State or Province
N/A
Zip or Postal Code
84170
Country
Israel
Email Address
lernervld@yahoo.com