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Awarded Trial: 02T-144
Grant ID
02T-144
Illness
BP
Primary Drug/Intervention
Chronobiological acceleration package (sleep deprivation/phase advance)
Primary Dosage
N/A
Secondary Drug Intervention
N/A
Secondary Dosage
N/A
Other Drug/Intervention
N/A
Other Dosage
N/A
Status
Completed
Investigator
Wu
Sample Size
62
Duration of Study Period for Each Subject
6 weeks
Outcome Measurements
HAM-D
Results
Patients with bipolar depression were randomized to receive standard psychotropic medication, or medication plus the chronobiological acceleration package. The chronobiological acceleration package included sleep deprivation, light treatment and phase advance of sleep. Patients receiving the acceleration package had a more rapid and robust antidepressant response than those receiving medication alone.
Publication
N/A
Link
N/A
PI Name
Joseph Wu
Degree
MD
Center
Department of Psychiatry and Human Behavior
Institution
The University of California, Irvine
Address
Brain Imaging Center, Irvine Hall
City or Town
Irvine
State or Province
CA
Zip or Postal Code
92697
Country
USA
Email Address
jcwu@uci.edu