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Awarded Trial: 02T-147
Grant ID
02T-147
Illness
Bipolar Substance Abuse
Primary Drug/Intervention
Quetiapine
Primary Dosage
100mg-600mg
Secondary Drug Intervention
Risperidone
Secondary Dosage
1.5mg-6mg
Other Drug/Intervention
N/A
Other Dosage
N/A
Status
Completed
Investigator
Nejtek
Sample Size
60
Duration of Study Period for Each Subject
20 weeks
Outcome Measurements
YMRS, IDS-C, SCQ-10, Iowa gambling task
Results
96 patients with BP and drug abuse were randomized to adjunct risperidone or quetiapine. No placebo group was included. Both antipsychotics produced significant improvement in manic, mixed, and depressive symptoms and in drug craving. The two antipsychotics did not differ significantly.
Publication
Nejtek VA, Avila M, Chen LA, Zielinski T, Djokovic M, Podawiltz A, Kaiser K, Bae S, Rush AJ. Do atypical antipsychotics effectively treat co-occurring bipolar disorder and stimulant dependence? A randomized, double-blind trial. J Clin Psychiatry 2008;69:1257-1266.
Link
http://www.ncbi.nlm.nih.gov/pubmed/18681757
PI Name
Vicki Nejtek
Degree
PhD
Center
Health Science Center at Fort Worth
Institution
University of North Texas
Address
1002 Montgomery St., Suite 210
City or Town
Fort Worth
State or Province
TX
Zip or Postal Code
76107
Country
USA
Email Address
vnejtek@hsc.unt.edu