Awarded Trial: 02T-147
Bipolar Substance Abuse
Secondary Drug Intervention
Duration of Study Period for Each Subject
YMRS, IDS-C, SCQ-10, Iowa gambling task
96 patients with BP and drug abuse were randomized to adjunct risperidone or quetiapine. No placebo group was included. Both antipsychotics produced significant improvement in manic, mixed, and depressive symptoms and in drug craving. The two antipsychotics did not differ significantly.
Nejtek VA, Avila M, Chen LA, Zielinski T, Djokovic M, Podawiltz A, Kaiser K, Bae S, Rush AJ. Do atypical antipsychotics effectively treat co-occurring bipolar disorder and stimulant dependence? A randomized, double-blind trial. J Clin Psychiatry 2008;69:1257-1266.
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