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Awarded Trial: 02T-181
Grant ID
02T-181
Illness
Bipolar Disorder
Primary Drug/Intervention
Celecoxib
Primary Dosage
200mg b.i.d.
Secondary Drug Intervention
N/A
Secondary Dosage
N/A
Other Drug/Intervention
N/A
Other Dosage
N/A
Status
Completed
Investigator
Soares
Sample Size
28
Duration of Study Period for Each Subject
6 weeks
Outcome Measurements
HAM-D, YMRS, CGI-BP, UKU side-effects scale
Results
Twenty eight patients completed the trial. Patients receiving celecoxib had a significant improvement on depression ratings at week 1, which did not persist in the subsequent weeks of the trial.
Publication
Nery FG, Monkul ES, Hatch JP, Fonseca M, Zunta-Soares GB, Frey BN, Bowden CL, Soares JC. Celecoxib as an adjunct in the treatment of depressive or mixed episodes of bipolar disorder: a double-blind, randomized, placebo-controlled study. Hum Psychopharmacol. 2008 Mar;23(2):87-94.
Link
http://www.ncbi.nlm.nih.gov/pubmed/18172906
PI Name
Jair Soares
Degree
MD
Center
Health Science Center at San Antonio
Institution
The University of Texas
Address
7703 Floyd Curl Drive
City or Town
San Antonio
State or Province
TX
Zip or Postal Code
78229
Country
USA
Email Address
soares@uthscsa.edu