Awarded Trial: 02T-271
Secondary Drug Intervention
Duration of Study Period for Each Subject
Glucose tolerance, insulin level, cognitive battery
Thirty-four patients were randomized and 20 completed the study. Patients receiving rosiglitazone experienced a significant improvement in effectiveness of glucose utilization and insulin sensitivity. There was no beneficial effect on cognition.
Henderson DC, Fan X, Sharma B, Copeland PM, Borba CP, Boxill R, Freudenreich O, Cather C, Eden Evins A, Goff DC. A double-blind, placebo-controlled trial of rosiglitazone for clozapine-induced glucose metabolism impairment in patients with schizophrenia. Acta Psychiatr Scand. 2009 Jun;119(6):457-65. Yi Z1, Fan X, Wang J, Liu D, Freudenreich O, Goff D, Henderson DC. Rosiglitazone and cognitive function in clozapine-treated patients with schizophrenia: a pilot study. Psychiatry Res. 2012 Dec 30;200(2-3):79-82.
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