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Awarded Trial: 03T-356

Grant ID

03T-356

Illness

Bipolar Disorder

Primary Drug/Intervention

Allopurinol

Primary Dosage

300 mg b.i.d.

Secondary Drug Intervention

Dipyridamole

Secondary Dosage

200mg b.i.d.

Other Drug/Intervention

N/A

Other Dosage

N/A

Status

Completed

Investigator

Machado-Vieira

Sample Size

180

Duration of Study Period for Each Subject

4 weeks

Outcome Measurements

YMRS

Results

One-hundred and sixty patients were randomized, and 139 patients completed the trial. There was a significant improvement in YMRS scores for patients treated with allopurinol, but not for those treated with dipyridamole. Eighty four percent of patients treated with allopurinol were considered to be responders (>50% improvement in YMRS) compared to 57% of patients treated with dipyridamole and 70% of patients given placebo.

Publication

Machado-Vieira R, Soares JC, Lara DR, Luckenbaugh DA, Busnello JV, Marca G, Cunha A, Souza DO, Zarate CA Jr, Kapczinski F. A double-blind, randomized, placebo-controlled 4-week study on the efficacy and safety of the purinergic agents allopurinol and dipyridamole adjunctive to lithium in acute bipolar mania. J Clin Psychiatry. 2008 Aug;69(8):1237-45.

Link

http://www.ncbi.nlm.nih.gov/pubmed/18681754

PI Name

Rodrigo Machado-Vieira

Degree

MD

Center

N/A

Institution

Hospital Espirita de Porto Alegre

Address

Praca Simoes Lopes Neto, 175 Teresopolis

City or Town

Porto Alegre

State or Province

RS

Zip or Postal Code

91,720.44

Country

Brazil

Email Address

rvieira@usp.br