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Awarded Trial: 03T-356
Grant ID
03T-356
Illness
Bipolar Disorder
Primary Drug/Intervention
Allopurinol
Primary Dosage
300 mg b.i.d.
Secondary Drug Intervention
Dipyridamole
Secondary Dosage
200mg b.i.d.
Other Drug/Intervention
N/A
Other Dosage
N/A
Status
Completed
Investigator
Machado-Vieira
Sample Size
180
Duration of Study Period for Each Subject
4 weeks
Outcome Measurements
YMRS
Results
One-hundred and sixty patients were randomized, and 139 patients completed the trial. There was a significant improvement in YMRS scores for patients treated with allopurinol, but not for those treated with dipyridamole. Eighty four percent of patients treated with allopurinol were considered to be responders (>50% improvement in YMRS) compared to 57% of patients treated with dipyridamole and 70% of patients given placebo.
Publication
Machado-Vieira R, Soares JC, Lara DR, Luckenbaugh DA, Busnello JV, Marca G, Cunha A, Souza DO, Zarate CA Jr, Kapczinski F. A double-blind, randomized, placebo-controlled 4-week study on the efficacy and safety of the purinergic agents allopurinol and dipyridamole adjunctive to lithium in acute bipolar mania. J Clin Psychiatry. 2008 Aug;69(8):1237-45.
Link
http://www.ncbi.nlm.nih.gov/pubmed/18681754
PI Name
Rodrigo Machado-Vieira
Degree
MD
Center
N/A
Institution
Hospital Espirita de Porto Alegre
Address
Praca Simoes Lopes Neto, 175 Teresopolis
City or Town
Porto Alegre
State or Province
RS
Zip or Postal Code
91,720.44
Country
Brazil
Email Address
rvieira@usp.br