Awarded Trial: 03T-413
up to 2000 mg/day
Secondary Drug Intervention
Duration of Study Period for Each Subject
Cognitive battery, PANSS, CGI, CDS, quality of life scales
In a double-blind trial, 75 patients with schizophrenia were randomized to L-carnosine, 2000 mg/d, for 3 months and assessed on a variety of cognitive tests. Patients on L-carnosine showed significant improvement on some tests of executive function, specifically set shifting and strategic target detection tests.
Chengappa KNR, Turkin SR, DeSanti S, Bowie CR, Brar JS, Schlicht PJ, Murphy SL, Hetrick ML, Bilder R, Fleet D. A preliminary, randomized, double-blind, placebo-controlled trial of L-carnosine to improve cognition in schizophrenia. Schizophr Res. 2012 Dec;142(1-3):145-52.
Western Psychiatric Institute and Clinic
University of Pittsburgh Medical Center
3811 O'Hara Street
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