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Awarded Trial: 03T-429
Grant ID
03T-429
Illness
Bipolar Depression
Primary Drug/Intervention
Mifepristone
Primary Dosage
600 mg
Secondary Drug Intervention
N/A
Secondary Dosage
N/A
Other Drug/Intervention
N/A
Other Dosage
N/A
Status
Completed
Investigator
Young
Sample Size
150
Duration of Study Period for Each Subject
6 weeks
Outcome Measurements
HAM-D, YMRS, CGI
Results
60 patients with BP depression were randomized to mifepristone 600 mg/d or placebo as an adjunct for 1 week. Spatial working memory was significantly improved at 2 weeks and was sustained for 7 weeks. There was no improvement in depressive symptoms.
Publication
Watson S, Gallagher P, Porter RJ, Smith MS, Herron LJ, Bulmer S; North-East Mood Disorders Clinical Research Group, Young AH, Ferrier IN. A Randomized Trial to Examine the Effect of Mifepristone on Neuropsychological Performance and Mood in Patients with Bipolar Depression. Biol Psychiatry. 2012;72:943-949.
Link
http://www.ncbi.nlm.nih.gov/pubmed/22770649
PI Name
Allan Young
Degree
PhD
Center
University of Newcastle
Institution
University of British Columbia
Address
2255 Wesbrook Mall
City or Town
Vancouver
State or Province
British Columbia
Zip or Postal Code
V6T 2A1
Country
Canada
Email Address
alyoung@interchange.ubc.ca