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Awarded Trial: 03T-472
Grant ID
03T-472
Illness
Psychosis (first episode)
Primary Drug/Intervention
B vitamins: Folic acid and Pyridoxine and Hydroxycobalamin
Primary Dosage
5mg and 50mg and 0.4mg
Secondary Drug Intervention
N/A
Secondary Dosage
N/A
Other Drug/Intervention
N/A
Other Dosage
N/A
Status
Completed
Investigator
O'Donnell
Sample Size
120
Duration of Study Period for Each Subject
3 months
Outcome Measurements
Cognitive battery, PANSS, CGI, HAM-D
Results
One hundred patients with first-episode psychosis were randomized to adjunct treatment with vitamin B6, B12, and folic acid or placebo. The treatment group improved significantly on depression symptoms and cognitive function (attention, working memory, and visual learning).
Publication
N/A
Link
N/A
PI Name
Colin O'Donnell
Degree
MB
Center
N/A
Institution
University of Melbourne
Address
35 Poplar Road, Locked Bag 10
City or Town
Parkville
State or Province
Victoria
Zip or Postal Code
3052
Country
Australia
Email Address
colin.o'donnell@mh.org.au