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Awarded Trial: 04T-580
Grant ID
04T-580
Illness
Schizophrenia
Primary Drug/Intervention
Ondansetron
Primary Dosage
8 mg
Secondary Drug Intervention
Haloperidol
Secondary Dosage
4-20 mg/day
Other Drug/Intervention
N/A
Other Dosage
N/A
Status
Completed
Investigator
Zhang
Sample Size
120
Duration of Study Period for Each Subject
12 weeks
Outcome Measurements
PANSS, CGI-S, TESS, ESRS
Results
One hundred twenty one patients with treatment resistant schizophrenia were given ondansetron or placebo adjunctively to haloperidol (4-20 mg/day). Ondansetron treatment was associated with significant improvement in PANSS total, negative symptoms and general symptoms. Ondansetron-treated patients also had fewer extrapyramidal side effects.
Publication
Zhang ZJ, Kang WH, Li Q, Wang XY, Yao SM, Ma AQ. Beneficial effects of ondansetron as an adjunct to haloperidol for chronic, treatment-resistant schizophrenia: A double-blind, randomized, placebo-controlled study. Schizophr Res. 2006 Dec;88(1-3):102-10. Epub 2006 Sep 7.
Link
http://www.ncbi.nlm.nih.gov/pubmed/16959472
PI Name
Zhang-Jin Zhang
Degree
MD
Center
Department of Psychiatry
Institution
The First Hospital, Xi'an Jiaotong University College of Medicine
Address
1 Jian Kang Road
City or Town
Xi'an
State or Province
Shaanxi Province
Zip or Postal Code
710061
Country
China
Email Address
zhangz68@yahoo.com