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Awarded Trial: 04T-624

Grant ID

04T-624

Illness

Bipolar Disorder

Primary Drug/Intervention

Folate, B6, B12

Primary Dosage

10 mg/day

Secondary Drug Intervention

B6

Secondary Dosage

80 mg/day

Other Drug/Intervention

B12

Other Dosage

2 mg/day

Status

Completed

Investigator

Dittmann

Sample Size

90

Duration of Study Period for Each Subject

2 years

Outcome Measurements

Cognitive battery, CGI-BP, HAM-D, YMRS

Results

In an attempt to improve cognitive function in patients with BP I or II, randomized 47 patients with an elevated homocycsteine level to folate 10 mg/d plus vitamin B-12, or placebo. On measures of cognitive function (RBANS, Trail Making Test), there was no difference between the groups among the 41 patients who completed the study.

Publication

Being submitted for publication.

Link

N/A

PI Name

Sandra Dittmann

Degree

PhD

Center

University of Munich

Institution

Ludwig-Maximilians Universitaet

Address

Nussbaumstr. 7

City or Town

Munich

State or Province

N/A

Zip or Postal Code

80336

Country

Germany

Email Address

sandra.dittmann@med.uni-muenchen.de