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Awarded Trial: 05T-680

Grant ID

05T-680

Illness

Bipolar Disorder

Primary Drug/Intervention

Insulin

Primary Dosage

40 IU q.i.d.

Secondary Drug Intervention

N/A

Secondary Dosage

N/A

Other Drug/Intervention

N/A

Other Dosage

N/A

Status

Completed

Investigator

McIntyre

Sample Size

60

Duration of Study Period for Each Subject

8 weeks

Outcome Measurements

HRSD, YMRS

Results

The objective was to assess the effects of intranasal insulin on cognitive function in euthymic BP patients. Sixty BP patients were randomized to intranasal insulin or placebo for 8 wks. Cognitive testing showed improvement in both groups but no significant difference between them.

Publication

Posthoc analysis: Yim CY, Soczynska JK, Kennedy SH, Woldeyohannes HO, Brietzke E, Intyre RS. The effect of overweight/obesity on cognitive function in euthymic individuals with bipolar disorders. Eur Psychiatry 2011 May 11.

Link

http://www.ncbi.nlm.nih.gov/pubmed/21570263

PI Name

Roger McIntyre

Degree

MD

Center

N/A

Institution

University of Toronto, University Health Network

Address

399 Bathurst Street, MP 9-325

City or Town

Toronto

State or Province

Ontario

Zip or Postal Code

M5T 2S8

Country

Canada

Email Address

roger.mcintyre@uhn.on.ca