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Awarded Trial: 05T-704
Grant ID
05T-704
Illness
Bipolar Disorder
Primary Drug/Intervention
Lamotrigine
Primary Dosage
25 mg/day
Secondary Drug Intervention
N/A
Secondary Dosage
N/A
Other Drug/Intervention
N/A
Other Dosage
N/A
Status
Completed
Investigator
Brown
Sample Size
120
Duration of Study Period for Each Subject
10 weeks
Outcome Measurements
Cocaine Craving Questionnaire , Hamilton Rating Scale, Quick Inventory of Depressive Symptomatology-SR, Young Mania Rating Scale, Barratt Impulsiveness Scale, Rey Auditory Verbal Learning Test, STROOP color-word task, Addiction Severity Index, PRD-III
Results
One hundred twenty (120) patients with bipolar disorder and cocaine dependence randomized to lamotrigine up to 400 mg/day or placebo control for 10 weeks. Data were available for 112 individuals. Lamotrigine was associated with a nonsignificant decrease in cocaine use in the first 2 weeks, but the effect appeared to wear off, and there was no difference at week 10. The lamotrigine also had no significant effect on symptoms or cognition.
Publication
Brown ES, Sunderajan P, Hu LT, Sowell SM, Carmody TJ. A Randomized, Double-Blind, Placebo-Controlled, Trial of Lamotrigine Therapy in Bipolar Disorder, Depressed or Mixed Phase and Cocaine Dependence. Neuropsychopharmacology 2012; 37:2347-2354.
Link
http://www.ncbi.nlm.nih.gov/pubmed/22669171
PI Name
E. Sherwood Brown
Degree
MD
Center
Southwestern Medical Center at Dallas
Institution
University of Texas
Address
5323 Harry Hines Boulevard
City or Town
Dallas
State or Province
TX
Zip or Postal Code
75390-8849
Country
USA
Email Address
Sherwood.Brown@utsouthwestern.edu