Back to Awarded Treatment Trials
Awarded Trial: 05T-742
Grant ID
05T-742
Illness
Schizophrenia
Primary Drug/Intervention
Estradiol Patches
Primary Dosage
100-200 mcg
Secondary Drug Intervention
N/A
Secondary Dosage
N/A
Other Drug/Intervention
N/A
Other Dosage
N/A
Status
Completed
Investigator
Kulkarni
Sample Size
180
Duration of Study Period for Each Subject
8 weeks
Outcome Measurements
PANSS, BPRS, MINI, MADRS, ASC
Results
180 women between ages of 18-45 with schizophrenia or schizoaffective disorder on antipsychotic medication were randomized to receive either transdermal estradiol 200 mcg, transdermal estradiol 100mcg, or a placebo patch. Both estradiol groups showed improvement in symptoms, as measured by decreases in PANSS positive, general, and total scores compared to the placebo group. A greater effect was observed in the higher dose of estradiol.
Publication
Kulkarni J, Gavrilidis E, Wang W, Worsley R, Fitzgerald PB, Gurvich C, Van Rheenen T, Berk M, Burger H. Estradiol for treatment-resistant schizophrenia: a large-scale randomize-controlled trial in women of child-bearing age. Mol Psychiatry. 2015 Jun;20(6):695-702.
Link
http://www.ncbi.nlm.nih.gov/pubmed/24732671
PI Name
Jayashri Kulkarni
Degree
PhD
Center
Alfred Psychiatry Research Centre
Institution
The Alfred Hospital
Address
Level 1, Old Baker Building, P.O. Box 315
City or Town
Prahran
State or Province
Victoria
Zip or Postal Code
3181
Country
Australia
Email Address
jayashri.kulkarni@med.monash.edu.au