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Awarded Trial: 06TGF-960
Grant ID
06TGF-960
Illness
Schizophrenia
Primary Drug/Intervention
Oxytocin
Primary Dosage
40 IU (delivered doses twice daily)
Secondary Drug Intervention
N/A
Secondary Dosage
N/A
Other Drug/Intervention
N/A
Other Dosage
N/A
Status
Completed
Investigator
Feifel
Sample Size
40
Duration of Study Period for Each Subject
6 weeks
Outcome Measurements
PANSS, HAM-A, CDSS, GAF, CGI
Results
Twenty (20) patients were included and 15 completed the 7-week trial. Each patient was given oxytocin nasal spray for 3 weeks and a placebo nasal spray for 3 weeks, with a 1-week washout period between treatments. The oxytocin treatment period resulted in a significant improvement in PANSS total, more marked for positive, than for negative, symptoms. The effect was seen only at the end of the 3-week trial, suggesting that a longer treatment period might produce more improvement.
Publication
N/A
Link
N/A
PI Name
David Feifel
Degree
MD
Center
N/A
Institution
UCSD Medical Center
Address
200 W. Arbor Dr.
City or Town
San Diego
State or Province
CA
Zip or Postal Code
92103-8218
Country
USA
Email Address
dfeifel@ucsd.edu