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Awarded Trial: 06TGF-960

Grant ID

06TGF-960

Illness

Schizophrenia

Primary Drug/Intervention

Oxytocin

Primary Dosage

40 IU (delivered doses twice daily)

Secondary Drug Intervention

N/A

Secondary Dosage

N/A

Other Drug/Intervention

N/A

Other Dosage

N/A

Status

Completed

Investigator

Feifel

Sample Size

40

Duration of Study Period for Each Subject

6 weeks

Outcome Measurements

PANSS, HAM-A, CDSS, GAF, CGI

Results

Twenty (20) patients were included and 15 completed the 7-week trial. Each patient was given oxytocin nasal spray for 3 weeks and a placebo nasal spray for 3 weeks, with a 1-week washout period between treatments. The oxytocin treatment period resulted in a significant improvement in PANSS total, more marked for positive, than for negative, symptoms. The effect was seen only at the end of the 3-week trial, suggesting that a longer treatment period might produce more improvement.

Publication

N/A

Link

N/A

PI Name

David Feifel

Degree

MD

Center

N/A

Institution

UCSD Medical Center

Address

200 W. Arbor Dr.

City or Town

San Diego

State or Province

CA

Zip or Postal Code

92103-8218

Country

USA

Email Address

dfeifel@ucsd.edu