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Awarded Trial: 07TGS-1025

Grant ID

07TGS-1025

Illness

Schizophrenia

Primary Drug/Intervention

Allopurinol

Primary Dosage

300 mg/bid

Secondary Drug Intervention

N/A

Secondary Dosage

N/A

Other Drug/Intervention

N/A

Other Dosage

N/A

Status

Completed

Investigator

Dickerson

Sample Size

34

Duration of Study Period for Each Subject

70 days

Outcome Measurements

PANSS, RBANS

Results

Fifty-two patients with schizophrenia received 600 mg of allopurinol or placebo for 8 weeks in a double-blind trial. Those receiving allopurinol had a greater improvement in their PANSS score; 4 of 27 had more than a 20 percent improvement, while 0 of the 24 controls had this much improvement. Also, 14 of the 27 on allopurionol reported subjective improvement compared to 4 of 25 on the placebo.

Publication

N/A

Link

N/A

PI Name

Faith Dickerson

Degree

PhD

Center

N/A

Institution

Sheppard Pratt

Address

6501 North Charles Street

City or Town

Baltimore

State or Province

MD

Zip or Postal Code

21204

Country

USA

Email Address

fdickerson@sheppardpratt.org