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Awarded Trial: 07TGS-1029
Grant ID
07TGS-1029
Illness
Bipolar Disorder and Schizoaffective Disorder
Primary Drug/Intervention
Pentazocine
Primary Dosage
50 mg, then 100 mg
Secondary Drug Intervention
Lorazepam
Secondary Dosage
.25 mg, then .05 mg
Other Drug/Intervention
N/A
Other Dosage
N/A
Status
Completed
Investigator
Cohen
Sample Size
20
Duration of Study Period for Each Subject
4 days
Outcome Measurements
YMRS, MACS Rating Scale
Results
This study compared pentazocine, an opiate, to lorazepam in patients with mania (bipolar or schizoaffective). Twenty patients were assigned to 100 mg pentazocine for 1 day or 0.5 mg of lorazepam for 1 day, then crossed over to the other drug on day 2. They were rated on the MACS (manic acute change scale) and YMRS. No difference was found in ratings between the two drugs.
Publication
Cohen BM, Murphy B. The effects of pentazocine, a kappa agonist, in patients with mania. Int J Neuropsychopharmacol. 2008 Mar;11(2):243-7.
Link
http://www.ncbi.nlm.nih.gov/pubmed/17897484
PI Name
Bruce Cohen
Degree
MD
Center
McLean Hospital
Institution
Frazier Research Institute
Address
115 Mill Street
City or Town
Belmont
State or Province
MA
Zip or Postal Code
2478
Country
USA
Email Address
cohenb@mcleanpo.mclean.org