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Awarded Trial: 07TGS-1051
Grant ID
07TGS-1051
Illness
Schizophrenia
Primary Drug/Intervention
Varenicline
Primary Dosage
0.5-2.0 mg
Secondary Drug Intervention
N/A
Secondary Dosage
N/A
Other Drug/Intervention
N/A
Other Dosage
N/A
Status
Completed
Investigator
Shim
Sample Size
120
Duration of Study Period for Each Subject
56 days
Outcome Measurements
PANSS, Simpson-Angus, CPT, the Digits Forward and Backward, the Visuospatial Memory Task, and the Wisconsin Card Sorting Test, MNWS, QSU-Brief, mCEO, SANS, DAI
Results
Randomized 120 patients to varenicline, a nicotinic receptor agonist, or placebo for 8 weeks in double-blind trial. No overall benefit for cognitive function, but for patients on second-generation antipsychotics there was improvement in attention. Detailed analysis underway.
Publication
Shim JC, Jung DU, Jung SS, Seo YS, Cho DM, Lee JH, Lee SW, Kong BG, Kang JW, Oh MK, Kim SD, McMahon RP, Kelly DL. Adjunctive Varenicline Treatment with Antipsychotic Medications for Cognitive Impairments in People with Schizophrenia: A Randomized Double-Blind Placebo-Controlled Trial. Neuropsychopharmacology. 2012 Feb;37(3):660-8.
Link
http://www.ncbi.nlm.nih.gov/pubmed/22048460
PI Name
Joo-Cheol Shim
Degree
MD
Center
Department of Psychiatry
Institution
Busan Paik Hospital
Address
633-165 Gaegum-Dong
City or Town
Busan
State or Province
Busanjin-Gu
Zip or Postal Code
614-735
Country
South Korea
Email Address
jooshim@inje.ac.kr