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Awarded Trial: 07TGS-1073

Grant ID

07TGS-1073

Illness

Bipolar Depression

Primary Drug/Intervention

S-adenosyl-methionine (SAMe)

Primary Dosage

200 mg/d at start of study/up to 1600 mg/d

Secondary Drug Intervention

N/A

Secondary Dosage

N/A

Other Drug/Intervention

N/A

Other Dosage

N/A

Status

Completed

Investigator

Murphy

Sample Size

10

Duration of Study Period for Each Subject

63 days

Outcome Measurements

CGI, YMRS, MADRS, GAF

Results

Twenty (20) subjects with BP were randomized to SAMe or placebos. There were no clinical or statistical differences between the groups on the HAM-D, MADRS, or YMRS> The dose of SAMe used was relatively low.

Publication

N/A

Link

N/A

PI Name

Beth Murphy

Degree

MD

Center

McLean Hospital

Institution

Frazier Research Institute

Address

115 Mill Street

City or Town

Belmont

State or Province

MA

Zip or Postal Code

2478

Country

USA

Email Address

murphyb@mcleanpo.mclean.org