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Awarded Trial: 07TGF-1126
Grant ID
07TGF-1126
Illness
Schizophrenia
Primary Drug/Intervention
Artemisinin
Primary Dosage
200 mg/day
Secondary Drug Intervention
N/A
Secondary Dosage
N/A
Other Drug/Intervention
N/A
Other Dosage
N/A
Status
Completed
Investigator
Dickerson
Sample Size
62
Duration of Study Period for Each Subject
12 weeks
Outcome Measurements
PANSS, RBANS, UPSA
Results
This was a study of artimisinin, an OTC Chinese herb from which antimalarial compounds are derived, as an adjunct for schizophrenia. Sixty-five (65) patients were randomized to artimisinin or placebo for 10 weeks, with a 2-week run-in. There was no difference in PANSS total between the groups overall. However, for patients who had antibodies to Toxoplasma gondii, against which artimisinin is thought to be moderately effective, the patients on artimisinin (n=8) improved significantly more than the patients on placebo (n=14) by ANOVA (F=2.89, p=0.0145).
Publication
Being submitted.
Link
N/A
PI Name
Faith Dickerson
Degree
PhD
Center
Department of Psychology
Institution
Sheppard Pratt
Address
6501 North Charles Street
City or Town
Baltimore
State or Province
MD
Zip or Postal Code
21204
Country
USA
Email Address
dickersonf@aol.com