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Awarded Trial: 10T-001
Grant ID
10T-001
Illness
Bipolar
Primary Drug/Intervention
Allopurinol
Primary Dosage
300 mg (2x per day)
Secondary Drug Intervention
N/A
Secondary Dosage
N/A
Other Drug/Intervention
N/A
Other Dosage
N/A
Status
Completed
Investigator
Weiser
Sample Size
180
Duration of Study Period for Each Subject
18 months
Outcome Measurements
N/A
Results
180 patients with acute mania, mean young mania rating score (YMRS)=25, were randomized to drug (n=90) or placebo (n=90); 82% completed the 6-wk study. At the end of the 6-wk trial, subjects on the drug improved by 10.8 YMRS points, and subjects on placebo improved by 11.3 YMRS points, with no difference between the groups, p=0.69. No significant side effects were reported. We conclude that allopurinol is not an effective treatment for acute mania.
Publication
Being submitted.
Link
N/A
PI Name
Mark Weiser
Degree
MD
Center
Psychiatric Outpatient Clinic
Institution
Sheba Medical Center
Address
Sheba Medical Center
City or Town
Tel-Hashomer
State or Province
N/A
Zip or Postal Code
52621
Country
Israel
Email Address
m.weiser@netvision.net.il