Grant ID

98-RC-301-2

Illness

Bipolar Disorder

Primary Drug/Intervention

Naltrexone

Primary Dosage

N/A

Secondary Drug Intervention

N/A

Secondary Dosage

N/A

Other Drug/Intervention

N/A

Other Dosage

N/A

Status

Completed

Investigator

Rush

Sample Size

50

Duration of Study Period for Each Subject

N/A

Outcome Measurements

N/A

Results

The effect of open-label naltrexone as add-on therapy was examined in 34 outpatients with bipolar disorder and alcohol dependence. Twenty-six patients returned for post-baseline assessments. Significant improvement was observed on the Hamilton Depression Rating Scale, and the Young Mania Rating Scale, but not on the Brief Psychiatric Rating Scale. Alcohol use and craving decreased significantly.

Publication

N/A

Link

N/A

PI Name

John Rush

Degree

MD

Center

UT Southwestern Medical Center

Institution

N/A

Address

City or Town

Dallas

State or Province

TX

Zip or Postal Code

N/A

Country

USA

Email Address

john.rush@utsouthwestern.edu