Grant ID

98-RC-301-1

Illness

Bipolar Disorder

Primary Drug/Intervention

Quetiapine

Primary Dosage

N/A

Secondary Drug Intervention

N/A

Secondary Dosage

N/A

Other Drug/Intervention

N/A

Other Dosage

N/A

Status

Completed

Investigator

Rush

Sample Size

30

Duration of Study Period for Each Subject

N/A

Outcome Measurements

N/A

Results

This pilot study examined the effect of neuroleptic discontinuation on cocaine and amphetamine use in patients with psychiatric illnesses. Twenty-four evaluable outpatients were randomized to continue (n=12) or discontinue (n=12) chronic neuroleptic therapy. The atypical antipsychotic, quetiapine, was instituted when necessary for psychosis in the discontinuation group. Participants were assessed weekly over 12 weeks with measures of psychiatric symptoms, drug use, and drug cravings. Those discontinuing neuroleptics (n=12) had significant reductions in drug cravings compared to those continuing neuroleptics. No significant between-group differences in drug use were found. A manuscript presenting these results is currently being reviewed for publication.

Publication

N/A

Link

N/A

PI Name

John Rush

Degree

MD

Center

UT Southwestern Medical Center

Institution

N/A

Address

City or Town

Dallas

State or Province

TX

Zip or Postal Code

N/A

Country

USA

Email Address

john.rush@utsouthwestern.edu