Grant ID

98-RC-312-4

Illness

Bipolar Disorder

Primary Drug/Intervention

Phenytoin

Primary Dosage

N/A

Secondary Drug Intervention

N/A

Secondary Dosage

N/A

Other Drug/Intervention

N/A

Other Dosage

N/A

Status

Completed

Investigator

Mishory

Sample Size

27

Duration of Study Period for Each Subject

N/A

Outcome Measurements

N/A

Results

Phenytoin is an effective anticonvulsant that has not previously been studied prophylactically in bipolar patients. Bipolar patients were studied who had at least one episode per year in the previous two years despite ongoing prophylaxis. Phenytoin or placebo was added to their current therapy in a double-blind cross-over design. Thirty observation periods of six months each were studied for 23 patients. Three patients had relapse on phenytoin and 9 had relapse on placebo. There was a significant prophylactic effect of phenytoin in bipolar disorder (Cox?s F-test for comparing survival in two groups: F (6, 18) = 3.44, p = 0.02). This study suggests prophylactic effects of add-on phenytoin in bipolar illness.

Publication

N/A

Link

N/A

PI Name

Alex Mishory

Degree

MD

Center

N/A

Institution

N/A

Address

City or Town

Beersheva

State or Province

N/A

Zip or Postal Code

N/A

Country

Israel

Email Address

mishory@barzi.health.gov.il