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Awarded Trial: 99-084
Grant ID
99-084
Illness
Depression
Primary Drug/Intervention
Repeated Transcranial Magnetic Stimulation (rTMS)
Primary Dosage
3 Hz and 10 Hz
Secondary Drug Intervention
Chlomipramine
Secondary Dosage
150 mg/day
Other Drug/Intervention
N/A
Other Dosage
N/A
Status
Completed
Investigator
Klein
Sample Size
59
Duration of Study Period for Each Subject
2 weeks / 10 daily sessions
Outcome Measurements
HDRS, BDI, CGI
Results
Fifty nine patients with major depression were randomized to receive: 1) left (n=12) or right (n=12) 3Hz rTMS with placebo medication; 2) left (n=10) or right (n=9) 10 Hz rTMS with placebo medication or 3) chlomipramine with sham rTMS (n=16). rTMS was administered to the prefrontal cortex daily for two weeks. There was no significant difference between groups with regard to Hamilton Depression Scores. There was a significantly higher proportion (55%) of treatment responders (reduction of Hamilton score by 50% or more) in the left 3Hz rTMS group. This treatment modality was also better tolerated and was associated with fewer dropouts.
Publication
Chistyakov AV, Kaplan B, Rubichek O, Kreinin I, Koren D, Feinsod M, Klein E. Antidepressant effects of different schedules of repetitive transcranial magnetic stimulation vs. chlomipramine in patients with major depression: relationship in changes in cortical excitability. Int J Neuropsychopharmacol. 2005 Jun;8(2):223-33.
Link
http://www.ncbi.nlm.nih.gov/pubmed/15569397
PI Name
Ehud Klein
Degree
MD
Center
Department of Psychiatry
Institution
Rambam Medical Center
Address
Bat Galim
City or Town
Haifa
State or Province
N/A
Zip or Postal Code
31096
Country
Israel
Email Address
e_klein@rambam.health.gov.il