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Awarded Trial: 99-102
Grant ID
99-102
Illness
BP Depression
Primary Drug/Intervention
Burst Suppression Therapy (BST) (Sevoflurane)
Primary Dosage
Inhaled anesthesia to produce 2 minutes of electrocerebral silence
Secondary Drug Intervention
N/A
Secondary Dosage
N/A
Other Drug/Intervention
N/A
Other Dosage
N/A
Status
Completed
Investigator
Early
Sample Size
40
Duration of Study Period for Each Subject
4 treatments
Outcome Measurements
HAM-D, HDRS, BDRS
Results
In an open label study of sevoflurane burst suppression therapy (BST) in 40 patients with treatment-resistant depression 78% experienced at least a 50% reduction in HAM-D scores. BST was generally well tolerated. To follow-up this result, a larger, controlled comparison to bifrontal ECT has been funded by SMRI and is in progress.
Publication
N/A
Link
N/A
PI Name
Terence Early
Degree
MD
Center
Medical Branch at Galveston
Institution
University of Texas
Address
301 University Boulevard, Rt. 0186, Rm. 1.402
City or Town
Galveston
State or Province
TX
Zip or Postal Code
77555
Country
USA
Email Address
early@bcm.tmc.edu