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Awarded Trial: 02T-170
Grant ID
02T-170
Illness
Major Depression
Primary Drug/Intervention
Triiodothyronine
Primary Dosage
40-50 mcg
Secondary Drug Intervention
N/A
Secondary Dosage
N/A
Other Drug/Intervention
Sertraline
Other Dosage
100mg/d
Status
Completed
Investigator
Lerer
Sample Size
124
Duration of Study Period for Each Subject
8 weeks
Outcome Measurements
CGI, HAM-D, HAM-A, BPRS, Visual Analogue Scale
Results
One hundred twenty-four patients were randomized to treatment and 77 completed 8 weeks of treatment. Patients receiving T3 were more likely to achieve a response (37%) than those receiving placebo (25%) and were also more likely to achieve remission (34% vs. 21%).
Publication
Cooper-Kazaz R, Apter JT, Cohen R, Karagichev L, Muhammed-Moussa S, Grupper D, Drori T, Newman ME, Sackeim HA, Glaser B, Lerer B. Combined treatment with sertraline and liothyronine in major depression: a randomized, double-blind, placebo-controlled trial. Arch Gen Psychiatry. 2007 Jun;64(6):679-88.
Link
http://www.ncbi.nlm.nih.gov/pubmed/17548749
PI Name
Bernard Lerer
Degree
MD
Center
Biological Psychiatry Laboratory, Department of Psychiatry
Institution
Hadassah-Hebrew University Medical Center
Address
Ein Karem
City or Town
Jerusalem
State or Province
N/A
Zip or Postal Code
91120
Country
Israel
Email Address
lerer@cc.huji.ac.il