Grant ID

02T-117

Illness

Schizophrenia

Primary Drug/Intervention

Topiramate

Primary Dosage

300mg

Secondary Drug Intervention

N/A

Secondary Dosage

N/A

Other Drug/Intervention

N/A

Other Dosage

N/A

Status

Completed

Investigator

Tiihonen

Sample Size

100

Duration of Study Period for Each Subject

12 weeks

Outcome Measurements

PANSS, CGI

Results

Twenty six hospitalized treatment-resistant patients with schizophrenia participated. Topiramate was more effective than placebo in reducing PANSS general psychopathology scores whereas no significant improvement was observed for positive or negative symptoms.

Publication

Tiihonen J, Halonen P, Wahlbeck K, Repo-Tiihonen E, Hyvärinen S, Eronen M, Putkonen H, Takala P, Mehtonen OP, Puck M, Oksanen J, Koskelainen P, Joffe G, Aer J, Hallikainen T, Ryynänen OP, Tupala E. Topiramate Add-On in Treatment Resistant Schizophrenia: A Randomized Double Blind, Placebo-Controlled, Crossover Trial. J Clin Psychiatry. 2005 Aug;66(8):1012-5.

Link

http://www.ncbi.nlm.nih.gov/pubmed/16086616

PI Name

Jari Tiihonen

Degree

MD

Center

Department of Forensic Psychiatry

Institution

University of Kuopio, Niuvanniemi Hospital

Address

City or Town

Kuopio

State or Province

N/A

Zip or Postal Code

70240

Country

Finland

Email Address

jari.tiihonen@niuva.fi