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Awarded Trial: 02T-162
Grant ID
02T-162
Illness
Bipolar Disorder
Primary Drug/Intervention
Tamoxifen
Primary Dosage
80mg
Secondary Drug Intervention
N/A
Secondary Dosage
N/A
Other Drug/Intervention
N/A
Other Dosage
N/A
Status
Completed
Investigator
Yildiz-Yesiloglu
Sample Size
50
Duration of Study Period for Each Subject
3 weeks
Outcome Measurements
YMRS
Results
Forty-eight percent of patients in the tamoxifen group experienced a greater than 50% drop in YMRS scores, compared to 5% of patients in the placebo group.
Publication
Yildiz A, Guleryuz S, Ankerst DP, Ongür D, Renshaw PF. Protein kinase C inhibition in the treatment of mania: a double-blind, placebo-controlled trial of tamoxifen. Arch Gen Psychiatry. 2008;65:255-263.
Link
http://www.ncbi.nlm.nih.gov/pubmed/18316672
PI Name
Aysegul Yildiz-Yesiloglu
Degree
MD
Center
N/A
Institution
Ozmavikent Konut Yapi Kooperatifi
Address
Saffet Baba Sok, Huzur Mah, No. 27/12
City or Town
Narlidere
State or Province
Izmir
Zip or Postal Code
35320
Country
Turkey
Email Address
agul_yildiz@hotmail.com