Grant ID

98-RC-301-4

Illness

Bipolar Disorder

Primary Drug/Intervention

Adderall

Primary Dosage

N/A

Secondary Drug Intervention

N/A

Secondary Dosage

N/A

Other Drug/Intervention

N/A

Other Dosage

N/A

Status

Completed

Investigator

Rush

Sample Size

40

Duration of Study Period for Each Subject

N/A

Outcome Measurements

N/A

Results

Forty subjects, ages 6 to 17, with Bipolar I or II disorders and comorbid Attention Deficit Disorder were treated in an open label format with divalproex for 8 weeks. Divalproex was associated with significant improvements on the Young Mania Rating Scale but not on measures of Attention Deficit Disorder. Thirty subjects who had been stabilized on divalproex were then randomized to receive Adderall in a double-blind, placebo controlled, crossover design. Adderall was significantly more effective than placebo for Attention Deficit Disorder without significant worsening of manic sympoms.

Publication

N/A

Link

N/A

PI Name

John Rush

Degree

MD

Center

UT Southwestern Medical Center

Institution

N/A

Address

City or Town

Dallas

State or Province

TX

Zip or Postal Code

N/A

Country

USA

Email Address

john.rush@utsouthwestern.edu