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Awarded Trial: 00-105
Grant ID
00-105
Illness
Schizophrenia
Primary Drug/Intervention
Estradiol
Primary Dosage
100mcg
Secondary Drug Intervention
N/A
Secondary Dosage
N/A
Other Drug/Intervention
N/A
Other Dosage
N/A
Status
Completed
Investigator
Kulkarni
Sample Size
69
Duration of Study Period for Each Subject
4 weeks
Outcome Measurements
PANSS, Cognitive measures
Results
69 patients with schizophrenia were randomized to receive transdermal estradiol or placebo. Patients receiving estrogen treatment showed significant improvements in PANSS total, PANSS positive, PANSS negative and PANSS general symptom ratings. Estrogen-treated patients also showed significant benefit on measures of short-term memory.
Publication
Arch Womens Ment Health. 2002 Nov;5(3):99-104. A clinical trial of adjunctive oestrogen treatment in women with schizophrenia. Kulkarni J1, Riedel A, de Castella AR, Fitzgerald PB, Rolfe TJ, Taffe J, Burger H.
Link
http://www.ncbi.nlm.nih.gov/pubmed/12510212
PI Name
Jayashri Kulkarni
Degree
PhD
Center
Alfred Psychiatry Research Centre
Institution
The Alfred Hospital
Address
Level 1 Old Baker Building, P.O. Box 315
City or Town
Prahran
State or Province
Victoria
Zip or Postal Code
3181
Country
Australia
Email Address
jayashri.kulkarni@med.monash.edu.au