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Awarded Trial: 04T-496
Grant ID
04T-496
Illness
Bipolar Disorder
Primary Drug/Intervention
Folic Acid
Primary Dosage
5 mg
Secondary Drug Intervention
N/A
Secondary Dosage
N/A
Other Drug/Intervention
N/A
Other Dosage
N/A
Status
Completed
Investigator
Cowen
Sample Size
120
Duration of Study Period for Each Subject
12 months
Outcome Measurements
Mood and Feeling Questionairre, Internal State Scale
Results
112 young adults (ages 14-24) whose father and/or mother had BP or recurrent depression were randomized to folic acid 2.5 mg. or placebo for 3 years to try and prevent the onset of mood disorders in the young adults. Those continuing in the study at 12, 24 and 36 months were 87, 60, and 27. There was no difference in the development of mood disorders between those on folic acid (14%) and placebo (18%).
Publication
Submitted.
Link
N/A
PI Name
Philip Cowen
Degree
MD
Center
Warneford Hospital
Institution
University of Oxford
Address
Headington
City or Town
Oxford
State or Province
N/A
Zip or Postal Code
OX3 7JX
Country
United Kingdom
Email Address
phil.cowen@psych.ox.ac.uk