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Awarded Trial: 05T-670
Grant ID
05T-670
Illness
Bipolar Disorder
Primary Drug/Intervention
Pramipexole
Primary Dosage
0.5mg t.i.d.
Secondary Drug Intervention
N/A
Secondary Dosage
N/A
Other Drug/Intervention
N/A
Other Dosage
N/A
Status
Completed
Investigator
Malhotra
Sample Size
50
Duration of Study Period for Each Subject
8 weeks
Outcome Measurements
CARS-M, HAMD
Results
Fifty bipolar I and II patients were randomized to adjunct pramipexole 1.5 mg. or placebo to assess effect on cognition. Although it was initially hoped to use only euthymic patients, that did not prove to be feasible. 45 patients completed the study and among them the pramipexole had no significant effect on cognitive measures. However a post-hoc analysis of the 34 euthymic patients showed a significant improvement in processing speek and working memory.
Publication
Burdick KE, Braga RJ, Nnadi CU, Shaya Y, Stearns WH, Malhotra A. Placebo-Controlled Adjunctive Trial of Pramipexole in Patients with Bipolar Disorder: Targeting Cognitive Dysfunction. Journal of Clinical Psychiatry 2011.
Link
http://www.ncbi.nlm.nih.gov/pubmed/22152405
PI Name
Anil Malhotra
Degree
MD
Center
N/A
Institution
The Zucker Hillside Hospital-NSLIJHS
Address
75-59 263rd Street
City or Town
Glen Oaks
State or Province
NY
Zip or Postal Code
11004
Country
USA
Email Address
malhotra@lij.edu