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Awarded Trial: 02T-228
Grant ID
02T-228
Illness
BP Depression
Primary Drug/Intervention
Phototherapy
Primary Dosage
50 lux red light for 2 weeks, followed by 7,000 lux light for 2-week epochs of 15, 30, and 45 min
Secondary Drug Intervention
N/A
Secondary Dosage
N/A
Other Drug/Intervention
N/A
Other Dosage
N/A
Status
Completed
Investigator
Wisner
Sample Size
30
Duration of Study Period for Each Subject
26 weeks
Outcome Measurements
Hamilton Depression Rating Scale--Atypical Depression symptoms version
Results
Eleven patients completed the trial. Three of four patients who received morning light treatment experienced a switch to manic or mixed states. Five of seven subjects receiving midday light had a significant improvement in depression. The optimal response was observed at 45 or 60 minutes of therapy.
Publication
Sit D, Wisner KL, Hanusa BH, Stull S, Terman M. Light therapy for bipolar disorder: a case series in women. Bipolar Disord. 2007 Dec;9(8):918-27.
Link
http://www.ncbi.nlm.nih.gov/pubmed/18076544
PI Name
Katherine Wisner
Degree
MD
Center
Women's Behavioral Health CARE
Institution
Western Psychiatric Institute and Clinic
Address
3811 O'Hara Street
City or Town
Pittsburgh
State or Province
PA
Zip or Postal Code
15213
Country
USA
Email Address
wisnerkl@upmc.edu