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Awarded Trial: 07TGF-1100
Grant ID
07TGF-1100
Illness
Bipolar depression or major depression and amphetamine abuse/dependence
Primary Drug/Intervention
Citicoline
Primary Dosage
500-2000 mg/day
Secondary Drug Intervention
N/A
Secondary Dosage
N/A
Other Drug/Intervention
N/A
Other Dosage
N/A
Status
Completed
Investigator
Brown
Sample Size
30
Duration of Study Period for Each Subject
20 weeks
Outcome Measurements
YMRS, IDS-C, HVLT, Stroop, SMT, RMCPT, VAS
Results
Sixty (60) patients with bipolar depression or major depression and amphetamine abuse were treated with citicoline up to 2000 mg/day or placebo for 12 weeks. Those on citicoline stayed in the study significantly longer and had a significant improvement in depressive symptoms. There was no difference in the two groups in amphetamine use, YMRS, or cognition.
Publication
Brown SE, Gabrielson B. A randomized, double-blind, placebo-controlled trial of citicoline for bipolar and unipolar depression and methamphetamine dependence. Journal of Affective Disorders 2012; 143:257-260.
Link
http://www.ncbi.nlm.nih.gov/pubmed/22974472
PI Name
Edson Brown
Degree
MD
Center
Department of Psychiatry
Institution
UT Southwestern Medical Center
Address
5323 Harry Hines Blvd.
City or Town
Dallas
State or Province
TX
Zip or Postal Code
75390-8849
Country
USA
Email Address
sherwood.brown@utsouthwestern.edu