Back to Awarded Treatment Trials
Awarded Trial: 98-RC-301-7
Grant ID
98-RC-301-7
Illness
Bipolar disorder and recurrent major depression with history of substance abuse
Primary Drug/Intervention
Pregnenolone
Primary Dosage
100 mg/day
Secondary Drug Intervention
N/A
Secondary Dosage
N/A
Other Drug/Intervention
N/A
Other Dosage
N/A
Status
Completed
Investigator
Brown
Sample Size
70
Duration of Study Period for Each Subject
N/A
Outcome Measurements
HRSD, YMRS
Results
The pregnenolone group showed trends toward greater improvement, relative to placebo, on the HRSD and YMRS. A post hoc analysis of completers found a statistically significant reduction in HRSD scores with pregnenolone as compared to placebo. Pregnenolone appeared to be safe and well tolerated. Findings suggest that pregnenolone use may be associated with some improvement in manic and depressive symptoms but not cognition in depressed patients with a history of substance use.
Publication
Osuji IJ, Vera-Bolanos E, Carmody TJ, Brown ES. Pregnenolone for cognition and mood in dual diagnosis patients. Psychiatry Research 2010;178:309-312.
Link
N/A
PI Name
E. Sherwood Brown
Degree
MD
Center
N/A
Institution
University of Texas Southwestern Medical Center at Dallas
Address
5323 Harry Hines Blvd, MC8849
City or Town
Dallas
State or Province
TX
Zip or Postal Code
75390-8849
Country
N/A
Email Address
sherwood.brown@utsouthwestern.edu